The Role of Pharmacology in ED

As we get older, it is only natural for us to rely on prescription medications that can help improve our quality of life. You likely don’t think anything of it, but certain medications can have a large impact on your likelihood of developing erectile dysfunction. Medication such as antidepressants, antipsychotics, diuretics and cardiovascular drugs can impact your ability to achieve and maintain an erection. Here is more information regarding certain medications and their impact on erectile dysfunction.


Properties in antidepressants are linked to decreased libido, ejaculatory inhibition and erectile dysfunction as a whole. There are serotoninergic and anticholinergic properties in these medications that are responsible for these problems. Antidepressant drugs include sertraline, paroxetine, escitalopram and citalopram.

Antipsychotics (Neuroleptics)

Neuroleptic drugs such as lurasidone, clozapine, and asenaphine are proven to decrease libido and ejaculatory inhibition with or without priapism. This occurs due to hyperprolactinemia that results from dopamine receptor antagonism in the pituitary and hypothalamus. Other factors that may increase the chance of ED when taking neuroleptics includes weight gain, central nervous system sedation, and parkinsonism.

Drugs of Abuse

Drugs of abuse, such as alcohol and tobacco, are linked to erectile dysfunction. Chronic alcohol use can lead to abnormal endocrine function because of increased aromatization of androgen, the development of a peripheral autonomic neuropathy. Tobacco may cause vasoconstriction, endothelial damage and reduced penile flow.

If you have more questions about ED or you are determined to treat your ED, visit our erectile dysfunction clinic near Laguna Beach, CA, also serving the greater Orange County, Los Angeles and Beverly Hills areas. We utilize low-intensity shockwave therapy that is known to reverse ED for the long-term. Contact us today to get started!

Source: Dr. Tom Lue’s Atlas of Male Sexual Dysfunction

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